The Mamiya 645 AF is a medium format autofocus SLR shooting 6×4.5 cm frames on 120 and 220 roll film. It was Mamiya's first autofocus body in the 645 line, positioned as a professional system camera with interchangeable film backs and finders, and was succeeded by the 645 AFD.

Auction data for the 645 AF is thin: a single UK saleroom hammer result in 2020 reached £833, which gives a reference point but not a reliable spread. Because only one verified hammer price is on record, current 2026 values for a 645 AF body should be treated as indicative rather than firm, and condition, included back, and lens kit will move what an example sells for in either direction.