The Mamiya 645 AFD II is a medium-format autofocus SLR using the 6x4.5cm frame on 120/220 roll film, with optional digital back compatibility. It sits within Mamiya's 645 AFD line as the second iteration of the autofocus 645 system.

Sales data for the 645 AFD II is thin: a single UK auction hammer result of £500 in late 2025 is the only reference point available, so any sense of what the body is worth today rests on that lone wholesale figure rather than a true range. Because hammer prices exclude buyer's and seller's commission, the all-in cost to a winning bidder would have been higher, and a body's price can shift considerably with condition, accessories, and whether a digital back or film back is included.