The Mamiya 645 AFD is an autofocus medium-format SLR shooting 6×4.5cm frames on 120/220 roll film, with digital back compatibility via a dedicated interface. It was introduced around the turn of the 2000s as the first autofocus body in Mamiya's 645 line, positioned for professional studio and location work.

At UK auction in recent years, hammer prices for 645 AFD bodies have ranged from about £380 to £610, with the two recorded sales sitting on either side of a roughly £490 midpoint — a useful guide to what the camera is worth at saleroom level today in 2026. These are wholesale hammer results rather than retail asking prices, and condition, the presence of a working film back, and inclusion of a prism finder all move the value within that band.